John Dubé, Ph.D.

• National Institutes of Health Loan Repayment Program Recipient (2008)

SELECTED PUBLICATIONS

• Andreacci JL, Robertson RJ, dub JJ, Aaron DJ, Balasekaran G, Arslanian SA. 黑人与白人青春期前与青春期儿童最大耗氧量比较. Pediatr Res. 2004 Nov;56(5):706-13. PubMed PMID: 15319460.
• Commerford SR, Peng L, Dubé JJ, O'Doherty RM. 骨骼肌中SREBP-1c的体内调节:营养状况的影响, glucose, insulin, and leptin. Am J Physiol Regul Integr Comp Physiol. 2004 Jul;287(1):R218-27. PubMed PMID: 15001432.
• Goss FL, Robertson RJ, Swan PD, Harris GS, Trone GA, Dubé JJ, Utter AC. 测定大学生摔跤运动员身体组成的残肺量与预测残肺量的比较. J Strength Cond Res. 2004 May;18(2):281-5. PubMed PMID: 15141998.
• Andreacci JL, Robertson RJ, Dubé JJ, Aaron DJ, Dixon CB, Arslanian SA. 黑人和白人肥胖青少年最大耗氧量比较. Pediatr Res. 2005 Sep;58(3):478-82. PubMed PMID: 16148060.
• Robertson RJ, Goss FL, Andreacci JL, Dubé JJ, Rutkowski JJ, Frazee KM, Aaron DJ, Metz KF, Kowallis RA, Snee BM. 儿童omni -阻力运动量表感知运动强度的验证. Med Sci Sports Exerc. 2005 May;37(5):819-26. PubMed PMID: 15870636.
• Robertson RJ, Goss FL, Andreacci JL, Dubé JJ, Rutkowski JJ, Snee BM, Kowallis RA, Crawford K, Aaron DJ, Metz KF. Validation of the children's OMNI RPE scale for stepping exercise. Med Sci Sports Exerc. 2005 Feb;37(2):290-8. PubMed PMID: 15692326.
• Bhatt BA, Dubé JJ, Dedousis N, Reider JA, O'Doherty RM. 饮食性肥胖和急性高脂血症以纤维型依赖的方式降低大鼠骨骼肌中ikappabα的水平. Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R233-40. PubMed PMID: 16081881.
• Dubé JJ, Bhatt BA, Dedousis N, Bonen A, O'Doherty RM. Leptin, skeletal muscle lipids, and lipid-induced insulin resistance. Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R642-50. Epub 2007/05/11. doi: 10.1152/ajpregu.00133.2007. PubMed PMID: 17491114.
• Amati F, Dubé JJ, Shay C, Goodpaster BH. 运动训练和减肥对运动效率和底物氧化的单独和联合影响. J Appl Physiol (1985). 2008 Sep;105(3):825-31. PMCID:PMC2536819.
• dub JJ, Amati F, Stefanovic-Racic M, Toledo FG, Sauers SE, Goodpaster BH. 运动诱导的细胞内脂质和胰岛素抵抗的改变:运动员悖论的重新审视. Am J Physiol Endocrinol Metab. 2008 May;294(5):E882-8. PMCID:PMC3804891
• Amati F, Dubé JJ, Coen PM, Stefanovic-Racic M, Toledo FG, Goodpaster BH. 缺乏运动和肥胖是衰老过程中胰岛素抵抗的基础. Diabetes Care. 2009;32(8):1547-9. PMCID:PMC2713647.
• Amati F, Dubé JJ, Stefanovic-Racic M, Toledo FG, Goodpaster BH. 胰岛素敏感性的改善因亚临床甲状腺功能减退而减弱. Med Sci Sports Exerc. 2009 Feb;41(2):265-9. PubMed PMID: 19127201.
• Chomentowski P, dub JJ, Amati F, Stefanovic-Racic M, Zhu S, Toledo FG, goodpastbh. 适度的运动可以减轻骨骼肌质量的损失，这种损失发生在老年人故意限制热量引起的减肥中, overweight to obese adults. J Gerontol A Biol Sci Med Sci. 2009 May;64(5):575-80. PMCID:PMC2800807.
• Gonzalez-Pertusa J, Dubé J, Valle SR, Rosa TC, Takane KK, Mellado-Gil JM, Perdomo G, Vasavada RC, García-Ocaña. 肝细胞生长因子的新促凋亡作用:与棕榈酸酯协同引起胰腺ß-细胞凋亡. Endocrinology. 2010 April; 151(4): 1487–1498. PMCID:PMC2850223.
• Coen PM, dub JJ, Amati F, Stefanovic-Racic M, Ferrell RE, Toledo FG, goodpast BH. 胰岛素抵抗与I型肌细胞内较高的甘油三酯相关，但与伴随较高神经酰胺含量的II型肌细胞无关. Diabetes. 2010;59(1):80-8. PMCID:PMC2797948.
• 黄伟，Metlakunta A, deousis N，张鹏，Sipula I, dub JJ, Scott DK, O'Doherty RM. 肝库普弗细胞的消耗可以防止饮食诱导的肝脂肪变性和胰岛素抵抗的发展. Diabetes. 2010;59(2):347-57. PMCID:PMC2809951.
• Amati F, Dubé JJ, Alvarez-Carnero E, Edreira MM, Chomentowski P, Coen PM, Switzer GE, Bickel PE, Stefanovic-Racic M, Toledo FG, Goodpaster BH. Skeletal muscle triglycerides, diacylglycerols, 神经酰胺在胰岛素抵抗中的作用:耐力训练运动员的另一个悖论? Diabetes. 2011;60(10):2588-97. PMCID:PMC3178290.
• dub JJ, Amati F, Toledo FG, Stefanovic-Racic M, Rossi A, Coen P, Coen P, Goodpaster BH. Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide. Diabetologia. 2011;54(5):1147-56. PMCID:PMC3804898.
• Amati F, Pennant M, Azuma K, Dubé JJ, Toledo FG, Rossi AP, Kelley DE, 大腿下部皮下脂肪组织和较高的内脏腹部脂肪组织含量都有助于胰岛素抵抗. Obesity (Silver Spring, Md). 2012;20(5):1115-7. PMID: 22262160.
• Dubé JJ, Allison KF, Rousson V, Goodpaster BH, Amati F. 运动剂量和胰岛素敏感性:与糖尿病预防的相关性. Med Sci Sports Exerc. 2012 May;44(5):793-9. PMCID: PMC3328621.
• Finlin BS, Varma V, Nolen GT, dub J, Starnes CP, Rasouli N, Kern PA, Peterson CA. 在与巨噬细胞共培养过程中，DHA降低了分化肌管中萎缩相关的Fn14蛋白. J Nutr Biochem. 2012 Aug;23(8):885-91. PMCID: PMC3223324
• Coen PM, Hames KC, Leachman EM, Delany JP, Ritov VB, Menshikova EV, Dubé JJ, Toledo FG, Stefanovic-Racic M, Goodpaster BH. 严重肥胖患者骨骼肌氧化能力降低，神经酰胺升高，但二酰基甘油含量未升高. Obesity (Silver Spring, Md). 2013. PMCID:PMC4136513.
• Liang H, Tantiwong P, Sriwijitkamol A, Shanmugasundaram K, Mohan S, Espinoza S, Dubé JJ, Defronzo RA, Musi N. 血浆游离脂肪酸浓度持续降低对胰岛素信号和骨骼肌炎症的影响. J Physiol. 2013; 591(pt11):2897-909. PMCID: PMC3690693.
• Avin KG, Coen PM, Huang W, Stolz DB, Sowa GA, dub JJ, Goodpaster BH, O 'Doherty RM, Ambrosio F. Skeletal muscle as a regulator of the longevity protein, Klotho. Front Physiol. 2014 Jun 17;5:189. PMCID:PMC4060456.
• DeLany JP, dub JJ, Standley RA, Distefano G, goodpasth, Stefanovic-Racic M, Coen PM, Toledo FG. 非肥胖人群外周胰岛素敏感性和线粒体容量的种族差异. J Clin Endocrinol Metab. 2014 Aug 8:jc20142512.
• Dubé JJ, Coen PM,DiStefano G, Chacon AC, Helbling NL, Desimone ME, Stafanovic-Racic M, Hames KC, Despines AA, Toledo FGS, Goodpaster BH. Effects of acute lipid overload on skeletal muscle insulin resistance, metabolic flexibility, and mitochondrial performance. Am J Physiol Endocrinol Metab. 2014. Dec 15;307(12):E1117-24. PMCID:pending
• dub JJ, Sitnick MT, Schoiswohl G, Wills RC, Basantani MK, Cai L, Kershaw EE. Adipose triglyceride lipase (ATGL) deletion from adipocytes, but not skeletal myocytes impairs acute exercise performance in mice. Am J Physiol Endocrinol Metab. 2014. May 15; 308(10): E879-90. PMCID:pending
• Menshikova EV, Ritov VB, dub JJ, Amati F, Stefanovic-Racic M, Toledo FGS, Coem PM, goodpast BH. 热量限制引起的减肥和运动对骨骼肌线粒体的影响不同，尽管对胰岛素敏感性的影响相似. J Gerontol A Biol Sci Med Sci. 2017 Feb 2 [Epub ahead of print]. PMCID pending.
• Chow LS, Mashek DG, Wang Q, Shepherd SO, Goodpaster BH, Dubé JJ. 高胰岛素血症背景下急性生理性游离脂肪酸升高对纤维型特异性IMCL积累的影响. J Appl Physiol. 2017 Apr 27 [Epub ahead of print]. PMCID pending.
• Shepherd SO, Strauss JA, Wang Q, dub JJ, Goodpaster BH, Mashek DG, Chow LS. 训练改变了急性游离脂肪酸暴露后肌肉中肌外蛋白的分布. J Physiol. In press.

SELECTED PRESENTATIONS

• “Self-induced Sensorimotor Sports & Recreation Injuries Among Adolescents”. American College of Sports Medicine Annual Meeting, Baltimore, MD. June 2001
• 不同BMI的儿童在跑步机上运动时基质利用的比较. American College of Sports Medicine Annual Meeting, St. Louis, MO. June 2002
• 《足球波胆平台》. American College of Sports Medicine Annual Meeting, San Francisco, CA. May 2003
• “高瘦素血症预防急性高脂血症引起的胰岛素抵抗”. American Diabetes Association 65th Scientific Sessions, San Diego, CA. June 2005
• “运动和减肥对老年肥胖者胰岛素抵抗和心脏代谢风险的单独影响”. American Diabetes Association 67th Scientific Sessions, Chicago. June 2007
• 肥胖老年人运动训练后基质的可利用性和利用. American College of Sports Medicine 55th Annual Meeting. May 2008
• “Lipid-induced insulin resistance: Good news, bad news”. University of Kentucky Graduate Center for Nutritional Sciences seminar. January 2010
• “高氧化肌肉不能避免急性脂质诱导的胰岛素抵抗”, Oral presentation American Diabetes Association Scientific Sessions. June 2012
• 肥胖和2型糖尿病患者胰岛素和代谢不灵活性对丙二酰辅酶a合成的影响. AC Chacon, EV Menshikova, JP DeLany, VB Ritov and JJ Dubé. Poster presentation American Diabetes Association Scientific Sessions. June 2012
• Invited speaker. American Diabetes Association 73rd Scientific Sessions. 题目:“运动与脂质中间体——运动揭示了什么脂肪毒性”. June 2013